Assay Detail
Binding
CHEMBL3411459
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Binding affinity to human N-terminal His-tagged XIAP BIR2-3 C202A/C213G mutant after 60 mins by HTRF assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.36 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410875 | — | — | 1 | 8.89 |
| CHEMBL3410879 | — | — | 1 | 8.82 |
| CHEMBL3410878 | — | — | 1 | 8.64 |
| CHEMBL3410877 | — | — | 1 | 8.60 |
| CHEMBL3410872 | — | — | 1 | 8.57 |
| CHEMBL3410874 | — | — | 1 | 8.49 |
| CHEMBL3410808 | — | — | 1 | 8.46 |
| CHEMBL3339214 | — | — | 1 | 8.40 |
| CHEMBL3410871 | — | — | 1 | 8.40 |
| CHEMBL3410807 | — | — | 1 | 8.33 |
| CHEMBL3410876 | — | — | 1 | 8.26 |
| CHEMBL3410809 | — | — | 1 | 8.16 |
| CHEMBL3410873 | — | — | 1 | 8.11 |
| CHEMBL3039522 | BIRINAPANT | 2.0 | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410875 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3410879 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3410878 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3410877 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3410872 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3410874 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3410808 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3339214 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3410871 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3410807 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3410876 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3410809 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3410873 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3039522 | BIRINAPANT | IC50 | = | 126.0 | nM | 6.90 |