Assay Detail
Functional
CHEMBL3411462
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Cytotoxicity against cIAP/XIAP-dependent human MDA-MB-231 cells assessed as cell viability after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.68 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410879 | — | — | 1 | 9.52 |
| CHEMBL3410877 | — | — | 1 | 9.10 |
| CHEMBL3410878 | — | — | 1 | 9.05 |
| CHEMBL3410876 | — | — | 1 | 8.92 |
| CHEMBL3410872 | — | — | 1 | 8.89 |
| CHEMBL3339214 | — | — | 1 | 8.82 |
| CHEMBL3410809 | — | — | 1 | 8.72 |
| CHEMBL3410875 | — | — | 1 | 8.70 |
| CHEMBL3410871 | — | — | 1 | 8.57 |
| CHEMBL3410874 | — | — | 1 | 8.55 |
| CHEMBL3410807 | — | — | 1 | 8.34 |
| CHEMBL3410808 | — | — | 1 | 8.21 |
| CHEMBL3410873 | — | — | 1 | 8.10 |
| CHEMBL3039522 | BIRINAPANT | 2.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410879 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3410877 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3410878 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3410876 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3410872 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3339214 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3410809 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3410875 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3410871 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3410874 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3410807 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3410808 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3410873 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3039522 | BIRINAPANT | IC50 | = | 10.0 | nM | 8.00 |