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Assay Detail

CHEMBL3411566

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 15 mins by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.
Mohammadi-Khanaposhtani M, Saeedi M, Zafarghandi NS, Mahdavi M, Sabourian R, Razkenari EK, Alinezhad H, Khanavi M, Foroumadi A, Shafiee A, Akbarzadeh T.
Eur J Med Chem (2015) 92 : 799 -806
PubMed 25636055 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.54 5.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3410478 1 5.14
CHEMBL636 RIVASTIGMINE 4.0 1 4.96
CHEMBL3410483 1 4.96
CHEMBL3410475 1 4.75
CHEMBL3410477 1 4.62
CHEMBL3410485 1 4.61
CHEMBL3410476 1 4.42
CHEMBL3410480 1 4.34
CHEMBL3410481 1 4.28
CHEMBL3410473 1 4.22
CHEMBL3410479 1 4.17
CHEMBL3410474 1 4.05
CHEMBL3410484 1 -
CHEMBL3410482 1 -
CHEMBL3410472 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3410478 IC50 = 7310.0 nM 5.14
CHEMBL636 RIVASTIGMINE IC50 = 11070.0 nM 4.96
CHEMBL3410483 IC50 = 10840.0 nM 4.96
CHEMBL3410475 IC50 = 17690.0 nM 4.75
CHEMBL3410477 IC50 = 23990.0 nM 4.62
CHEMBL3410485 IC50 = 24530.0 nM 4.61
CHEMBL3410476 IC50 = 38330.0 nM 4.42
CHEMBL3410480 IC50 = 45570.0 nM 4.34
CHEMBL3410481 IC50 = 52820.0 nM 4.28
CHEMBL3410473 IC50 = 59680.0 nM 4.22
CHEMBL3410479 IC50 = 68060.0 nM 4.17
CHEMBL3410474 IC50 = 88100.0 nM 4.05
CHEMBL3410484 IC50 >= 100000.0 nM -
CHEMBL3410482 IC50 >= 100000.0 nM -
CHEMBL3410472 IC50 >= 100000.0 nM -