Assay Detail
Binding
CHEMBL3411705
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Inhibition of HIV1 reverse transcriptase-associated DNA polymerase-independent RNase H activity after 1 hr
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.20 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3409201 | — | — | 1 | 5.60 |
| CHEMBL3409202 | — | — | 1 | 5.58 |
| CHEMBL2005185 | — | — | 1 | 5.55 |
| CHEMBL1968193 | — | — | 1 | 5.54 |
| CHEMBL1958265 | — | — | 1 | 5.50 |
| CHEMBL3409205 | — | — | 1 | 5.41 |
| CHEMBL3409204 | — | — | 1 | 5.33 |
| CHEMBL3409200 | — | — | 1 | 5.19 |
| CHEMBL3409203 | — | — | 1 | 5.05 |
| CHEMBL45578 | — | — | 1 | 5.00 |
| CHEMBL3409199 | — | — | 1 | 4.97 |
| CHEMBL1976117 | — | — | 1 | 4.83 |
| CHEMBL1976450 | — | — | 1 | 4.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3409201 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3409202 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2005185 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1968193 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1958265 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3409205 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3409204 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3409200 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3409203 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL45578 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3409199 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1976117 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1976450 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL223228 | EFAVIRENZ | IC50 | - | — | - |