Assay Detail
Binding
CHEMBL3411706
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Inhibition of HIV1 reverse transcriptase-associated RNA-dependent DNA polymerase activity after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.92 |
| CHEMBL1958265 | — | — | 1 | 6.05 |
| CHEMBL2005185 | — | — | 1 | 4.89 |
| CHEMBL3409202 | — | — | 1 | 4.73 |
| CHEMBL3409205 | — | — | 1 | 4.71 |
| CHEMBL3409199 | — | — | 1 | 4.70 |
| CHEMBL3409201 | — | — | 1 | 4.66 |
| CHEMBL3409200 | — | — | 1 | 4.62 |
| CHEMBL3409204 | — | — | 1 | 4.58 |
| CHEMBL1968193 | — | — | 1 | 4.47 |
| CHEMBL3409203 | — | — | 1 | 4.35 |
| CHEMBL1976450 | — | — | 1 | 4.14 |
| CHEMBL1976117 | — | — | 1 | 4.09 |
| CHEMBL45578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1958265 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2005185 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3409202 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL3409205 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3409199 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3409201 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3409200 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL3409204 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1968193 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3409203 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1976450 | — | IC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL1976117 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL45578 | — | IC50 | - | — | - |