Assay Detail
Binding
CHEMBL3412050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transactivation assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neurogenic locus notch homolog protein 1 (CHEMBL2146346) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410153 | — | — | 1 | 9.00 |
| CHEMBL3410163 | — | — | 1 | 9.00 |
| CHEMBL3410169 | — | — | 1 | 9.00 |
| CHEMBL3410151 | — | — | 1 | 8.70 |
| CHEMBL3410170 | — | — | 1 | 8.70 |
| CHEMBL3410167 | — | — | 1 | 8.70 |
| CHEMBL3410168 | — | — | 1 | 8.70 |
| CHEMBL3410152 | — | — | 1 | 8.52 |
| CHEMBL3410160 | — | — | 1 | 8.52 |
| CHEMBL3410162 | — | — | 1 | 8.52 |
| CHEMBL3410164 | — | — | 1 | 8.52 |
| CHEMBL3410161 | — | — | 1 | 8.40 |
| CHEMBL3410166 | — | — | 1 | 8.05 |
| CHEMBL3410154 | — | — | 1 | 7.89 |
| CHEMBL3410157 | — | — | 1 | 7.50 |
| CHEMBL3410159 | — | — | 1 | 7.27 |
| CHEMBL3410158 | — | — | 1 | 6.77 |
| CHEMBL3410156 | — | — | 1 | 6.64 |
| CHEMBL3410155 | — | — | 1 | 5.92 |
| CHEMBL3410165 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410153 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3410163 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3410169 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3410151 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3410170 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3410167 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3410168 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3410152 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3410160 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3410162 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3410164 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3410161 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3410166 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3410154 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3410157 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3410159 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3410158 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3410156 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL3410155 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3410165 | — | IC50 | = | 2060.0 | nM | 5.69 |