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Assay Detail

CHEMBL3412052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human TALL-1 cells assessed as cell number by coulter channelyzer
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type TALL-1
Confidence 1 — Organism
Curated By Autocuration

Target

TALL-1 (CHEMBL2366254)
Type CELL-LINE
Organism Homo sapiens

Publication

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.
Shan W, Balog A, Quesnelle C, Gill P, Han WC, Norris D, Mandal S, Thiruvenkadam R, Gona KB, Thiyagarajan K, Kandula S, McGlinchey K, Menard K, Wen ML, Rose A, White R, Guarino V, Shen DR, Cvijic ME, Ranasinghe A, Dai J, Zhang Y, Wu DR, Mathur A, Rampulla R, Trainor G, Hunt JT, Vite GD, Westhouse R, Lee FY, Gavai AV.
Bioorg Med Chem Lett (2015) 25 : 1905 -1909
PubMed 25857941 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.08 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3410151 1 8.52
CHEMBL3410161 1 8.40
CHEMBL3410166 1 8.40
CHEMBL3410168 1 8.40
CHEMBL3410169 1 8.40
CHEMBL3410170 1 8.40
CHEMBL3410167 1 8.30
CHEMBL3410163 1 7.89
CHEMBL3410162 1 7.82
CHEMBL3410164 1 7.58
CHEMBL3410154 1 6.80
CHEMBL3410152 1 -
CHEMBL3410153 1 -
CHEMBL3410165 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3410151 IC50 = 3.0 nM 8.52
CHEMBL3410161 IC50 = 4.0 nM 8.40
CHEMBL3410166 IC50 = 4.0 nM 8.40
CHEMBL3410168 IC50 = 4.0 nM 8.40
CHEMBL3410169 IC50 = 4.0 nM 8.40
CHEMBL3410170 IC50 = 4.0 nM 8.40
CHEMBL3410167 IC50 = 5.0 nM 8.30
CHEMBL3410163 IC50 = 13.0 nM 7.89
CHEMBL3410162 IC50 = 15.0 nM 7.82
CHEMBL3410164 IC50 = 26.0 nM 7.58
CHEMBL3410154 IC50 = 158.0 nM 6.80
CHEMBL3410152 IC50 - -
CHEMBL3410153 IC50 - -
CHEMBL3410165 IC50 - -