Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3412154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV genotype 1b I389luc-ubi-neo/NS3-3'/5.1 replicons infected in human Huh5-2 HCV subgenomic replicon-containing cells assessed as reduction in virus replication after 3 days by luciferase reporter gene assay
ChEMBL ↗
95
Total Activities
52
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
Rivero-Buceta E, Carrero P, Doyagüez EG, Madrona A, Quesada E, Camarasa MJ, Peréz-Pérez MJ, Leyssen P, Paeshuyse J, Balzarini J, Neyts J, San-Félix A.
Eur J Med Chem (2015) 92 : 656 -671
PubMed 25617695 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 52 4.94 6.40
EC90 43 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16121 DODECYL GALLATE — 2 6.40
CHEMBL3409789 — — 2 5.70
CHEMBL3409785 — — 2 5.60
CHEMBL231813 TELAPREVIR 4.0 1 5.55
CHEMBL3409790 — — 2 5.33
CHEMBL488853 — — 2 5.19
CHEMBL273804 HEXYL GALLATE — 2 5.05
CHEMBL593617 — — 1 4.96
CHEMBL3409784 — — 1 4.96
CHEMBL60350 — — 2 4.96
CHEMBL494005 BUTYL GALLATE — 2 4.89
CHEMBL3409782 — — 1 4.85
CHEMBL494006 PENTYL GALLATE — 2 4.85
CHEMBL3409781 — — 2 4.82
CHEMBL1164468 — — 1 4.80
CHEMBL3409772 — — 2 4.77
CHEMBL3409773 — — 2 4.75
CHEMBL453196 ETHYLGALLATE — 2 4.72
CHEMBL3409775 — — 1 4.70
CHEMBL3409774 — — 2 4.64
CHEMBL3409783 — — 1 4.60
CHEMBL3409776 — — 2 4.57
CHEMBL3409791 — — 1 4.55
CHEMBL3409786 — — 2 4.47
CHEMBL3409780 — — 2 4.47
CHEMBL3409771 — — 2 4.41
CHEMBL3409814 — — 2 -
CHEMBL3409787 — — 2 -
CHEMBL3409813 — — 2 -
CHEMBL3409812 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16121 DODECYL GALLATE EC50 = 400.0 nM 6.40
CHEMBL3409789 — EC50 = 2000.0 nM 5.70
CHEMBL3409785 — EC50 = 2500.0 nM 5.60
CHEMBL231813 TELAPREVIR EC50 = 2800.0 nM 5.55
CHEMBL3409790 — EC50 = 4700.0 nM 5.33
CHEMBL488853 — EC50 = 6500.0 nM 5.19
CHEMBL273804 HEXYL GALLATE EC50 = 9000.0 nM 5.05
CHEMBL593617 — EC50 = 11000.0 nM 4.96
CHEMBL3409784 — EC50 = 11000.0 nM 4.96
CHEMBL60350 — EC50 = 11000.0 nM 4.96
CHEMBL494005 BUTYL GALLATE EC50 = 13000.0 nM 4.89
CHEMBL3409782 — EC50 = 14000.0 nM 4.85
CHEMBL494006 PENTYL GALLATE EC50 = 14000.0 nM 4.85
CHEMBL3409781 — EC50 = 15000.0 nM 4.82
CHEMBL1164468 — EC50 = 16000.0 nM 4.80
CHEMBL3409772 — EC50 = 17000.0 nM 4.77
CHEMBL3409773 — EC50 = 18000.0 nM 4.75
CHEMBL453196 ETHYLGALLATE EC50 = 19000.0 nM 4.72
CHEMBL3409775 — EC50 = 20000.0 nM 4.70
CHEMBL3409774 — EC50 = 23000.0 nM 4.64
CHEMBL3409783 — EC50 = 25000.0 nM 4.60
CHEMBL3409776 — EC50 = 27000.0 nM 4.57
CHEMBL3409791 — EC50 = 28000.0 nM 4.55
CHEMBL3409786 — EC50 = 34000.0 nM 4.47
CHEMBL3409780 — EC50 = 34000.0 nM 4.47
CHEMBL3409771 — EC50 = 39000.0 nM 4.41
CHEMBL3409808 — EC50 - — -
CHEMBL3409808 — EC90 - — -
CHEMBL3409809 — EC90 - — -
CHEMBL3409810 — EC90 - — -
CHEMBL3409811 — EC90 - — -
CHEMBL3409812 — EC90 - — -
CHEMBL3409813 — EC90 - — -
CHEMBL3409805 — EC90 - — -
CHEMBL3409804 — EC50 - — -
CHEMBL3409805 — EC50 - — -
CHEMBL3409806 — EC50 - — -
CHEMBL3409807 — EC50 - — -
CHEMBL3409810 — EC50 - — -
CHEMBL3409809 — EC50 - — -
CHEMBL3409814 — EC90 - — -
CHEMBL3409811 — EC50 - — -
CHEMBL3409812 — EC50 - — -
CHEMBL3409813 — EC50 - — -
CHEMBL3409814 — EC50 - — -
CHEMBL3409793 — EC90 - — -
CHEMBL1303636 — EC90 - — -
CHEMBL3409794 — EC90 - — -
CHEMBL3409795 — EC90 - — -
CHEMBL3409796 — EC90 - — -