Assay Detail
Functional
CHEMBL3412342
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Cytotoxicity against human HepG2 cells assessed as surviving fraction ratio incubated for 2 hrs prior to 8Gy gamma-irradiation measured after 48 hrs by ELISA reader relative to control
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer and radiosensitizing evaluation of some novel sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.85 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3409822 | — | — | 1 | 5.30 |
| CHEMBL3409820 | — | — | 1 | 5.24 |
| CHEMBL3409817 | — | — | 1 | 4.94 |
| CHEMBL3409819 | — | — | 1 | 4.74 |
| CHEMBL3409823 | — | — | 1 | 4.70 |
| CHEMBL3407524 | — | — | 1 | 4.69 |
| CHEMBL3409825 | — | — | 1 | 4.63 |
| CHEMBL3409829 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3409822 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3409820 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3409817 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3409819 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3409823 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3407524 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL3409825 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL3409829 | — | IC50 | = | 26800.0 | nM | 4.57 |