Assay Detail
Binding
CHEMBL3412564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAKKK-CONH2 as substrate after 10 mins by scintillation counting in presence of [gamma-33P]ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the chemistry and biology of pyridopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.65 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30432 | GW282974X | — | 1 | 7.80 |
| CHEMBL3409483 | — | — | 1 | 7.68 |
| CHEMBL3409484 | — | — | 1 | 7.58 |
| CHEMBL3409482 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30432 | GW282974X | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3409483 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3409484 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3409482 | — | IC50 | = | 30.0 | nM | 7.52 |