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Assay Detail

CHEMBL3412745

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Binding
Inhibition of Pneumocystis carinii DHFR K37Q mutant by spectrophotometric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pneumocystis carinii
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dihydrofolate reductase (CHEMBL1926)
Type SINGLE PROTEIN
Organism Pneumocystis carinii

Publication

Recent advances in the chemistry and biology of pyridopyrimidines.
Buron F, Mérour JY, Akssira M, Guillaumet G, Routier S.
Eur J Med Chem (2015) 95 : 76 -95
PubMed 25794791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.59 9.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145979 1 9.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145979 Ki = 0.26 nM 9.59