Assay Detail
Binding
CHEMBL3412922
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Inhibition of calmodulin-dependent bovine neuronal NOS using [3H]-arginine as substrate assessed as citrulline formation after 30 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.60 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275066 | — | — | 1 | 4.60 |
| CHEMBL540 | IMIDAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275066 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL540 | IMIDAZOLE | IC50 | = | 200000.0 | nM | - |