Assay Detail
Functional
CHEMBL3413153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 1000 nM (Rvb = 7 to 14 pM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 10.17 | 10.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156605 | — | — | 1 | 10.41 |
| CHEMBL105775 | — | — | 1 | 9.92 |
| CHEMBL1269257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156605 | — | EC50 | = | 0.039 | nM | 10.41 |
| CHEMBL105775 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1269257 | — | EC50 | - | — | - |