Assay Detail
Binding
CHEMBL3413541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human recombinant dopamine D2 receptor expressed in CHOK1 cells incubated for 60 mins by scintillation counting method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.45 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3409242 | — | — | 1 | 8.89 |
| CHEMBL3409238 | — | — | 1 | 8.89 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.40 |
| CHEMBL3409234 | — | — | 1 | 8.32 |
| CHEMBL3409240 | — | — | 1 | 8.21 |
| CHEMBL3409256 | — | — | 1 | 8.20 |
| CHEMBL3409239 | — | — | 1 | 7.96 |
| CHEMBL3409241 | — | — | 1 | 7.92 |
| CHEMBL3407518 | — | — | 1 | 7.85 |
| CHEMBL3409237 | — | — | 1 | 7.70 |
| CHEMBL3409250 | — | — | 1 | 7.68 |
| CHEMBL3409254 | — | — | 1 | 7.64 |
| CHEMBL3409245 | — | — | 1 | 7.54 |
| CHEMBL3409243 | — | — | 1 | 7.51 |
| CHEMBL3409233 | — | — | 1 | 7.40 |
| CHEMBL3409252 | — | — | 1 | 7.36 |
| CHEMBL3409251 | — | — | 1 | 7.35 |
| CHEMBL3409263 | — | — | 1 | 7.33 |
| CHEMBL3409246 | — | — | 1 | 7.21 |
| CHEMBL3409261 | — | — | 1 | 7.21 |
| CHEMBL3409262 | — | — | 1 | 7.17 |
| CHEMBL3409235 | — | — | 1 | 7.16 |
| CHEMBL3409232 | — | — | 1 | 7.14 |
| CHEMBL3409253 | — | — | 1 | 7.12 |
| CHEMBL3409257 | — | — | 1 | 7.11 |
| CHEMBL3409249 | — | — | 1 | 7.02 |
| CHEMBL3409258 | — | — | 1 | 6.96 |
| CHEMBL3409236 | — | — | 1 | 6.92 |
| CHEMBL3409259 | — | — | 1 | 6.92 |
| CHEMBL3409244 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3409242 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3409238 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3409234 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3409240 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL3409256 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL3409239 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3409241 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3407518 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3409237 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3409250 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3409254 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3409245 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3409243 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3409233 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3409252 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL3409251 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL3409263 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL3409246 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3409261 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3409262 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL3409235 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3409232 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL3409253 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3409257 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3409249 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL3409258 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3409236 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3409259 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3409244 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3409248 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3409255 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3409247 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3409260 | — | Ki | = | 290.0 | nM | 6.54 |