Assay Detail

CHEMBL3413823

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Functional

Antiviral activity against Respiratory syncytial virus clinical isolates

ChEMBL ↗

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Target

Respiratory syncytial virus (CHEMBL612679) ↗

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Primary target Respiratory syncytial virus

CHEMBL612679

Anchored from Assay target.

Protein identity Respiratory syncytial virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Respiratory syncytial virus
Confidence	1 — Organism
Curated By	Autocuration

Target

Respiratory syncytial virus (CHEMBL612679) ↗

Type	ORGANISM
Organism	Respiratory syncytial virus

Publication

Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.

Mackman RL, Sangi M, Sperandio D, Parrish JP, Eisenberg E, Perron M, Hui H, Zhang L, Siegel D, Yang H, Saunders O, Boojamra C, Lee G, Samuel D, Babaoglu K, Carey A, Gilbert BE, Piedra PA, Strickley R, Iwata Q, Hayes J, Stray K, Kinkade A, Theodore D, Jordan R, Desai M, Cihlar T.
J Med Chem (2015) 58 : 1630 -1643
PubMed 25574686 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	10.00	10.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3410450	PRESATOVIR	2.0	1	10.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3410450	PRESATOVIR	EC50	=	0.1	nM	10.00