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Assay Detail

CHEMBL3413935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE using acetylthiocholine substrate by Ellman's reagent based method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.
Baharloo F, Moslemin MH, Nadri H, Asadipour A, Mahdavi M, Emami S, Firoozpour L, Mohebat R, Shafiee A, Foroumadi A.
Eur J Med Chem (2015) 93 : 196 -201
PubMed 25681712 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.90 8.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3408398 1 8.39
CHEMBL3408242 1 8.31
CHEMBL3408397 1 8.24
CHEMBL3408241 1 8.17
CHEMBL3408403 1 8.09
CHEMBL3408401 1 8.06
CHEMBL3408400 1 8.02
CHEMBL3408408 1 7.97
CHEMBL3408399 1 7.87
CHEMBL3408243 1 7.80
CHEMBL3408405 1 7.72
CHEMBL3408406 1 7.65
CHEMBL3408404 1 7.58
CHEMBL3408407 1 7.53
CHEMBL1678 DONEPEZIL HYDROCHLORIDE 4.0 1 7.51
CHEMBL3408402 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3408398 IC50 = 4.1 nM 8.39
CHEMBL3408242 IC50 = 4.9 nM 8.31
CHEMBL3408397 IC50 = 5.8 nM 8.24
CHEMBL3408241 IC50 = 6.8 nM 8.17
CHEMBL3408403 IC50 = 8.1 nM 8.09
CHEMBL3408401 IC50 = 8.7 nM 8.06
CHEMBL3408400 IC50 = 9.6 nM 8.02
CHEMBL3408408 IC50 = 10.6 nM 7.97
CHEMBL3408399 IC50 = 13.5 nM 7.87
CHEMBL3408243 IC50 = 16.0 nM 7.80
CHEMBL3408405 IC50 = 18.9 nM 7.72
CHEMBL3408406 IC50 = 22.4 nM 7.65
CHEMBL3408404 IC50 = 26.5 nM 7.58
CHEMBL3408407 IC50 = 29.5 nM 7.53
CHEMBL1678 DONEPEZIL HYDROCHLORIDE IC50 = 31.0 nM 7.51
CHEMBL3408402 IC50 = 31.5 nM 7.50