Assay Detail
Binding
CHEMBL3414093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.15 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3407538 | — | — | 1 | 6.60 |
| CHEMBL3407536 | — | — | 1 | 6.14 |
| CHEMBL1200374 | EXEMESTANE | 4.0 | 1 | 6.05 |
| CHEMBL3407539 | — | — | 1 | 6.01 |
| CHEMBL3407537 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3407538 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3407536 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1200374 | EXEMESTANE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3407539 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3407537 | — | IC50 | = | 1180.0 | nM | 5.93 |