Assay Detail
Functional
CHEMBL3418110
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Cytotoxicity against human HepG2 cells by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of isocryptolepine analogues and their structure-activity relationship studies as antiplasmodial and antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.49 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.40 |
| CHEMBL3415868 | — | — | 1 | 6.19 |
| CHEMBL596333 | ISOCRYPTOLEPINE | — | 1 | 6.14 |
| CHEMBL3415873 | — | — | 1 | 6.12 |
| CHEMBL3415869 | — | — | 1 | 6.09 |
| CHEMBL3415871 | — | — | 1 | 5.86 |
| CHEMBL3415872 | — | — | 1 | 5.66 |
| CHEMBL3415875 | — | — | 1 | 5.59 |
| CHEMBL3415874 | — | — | 1 | 5.58 |
| CHEMBL3415876 | — | — | 1 | 5.58 |
| CHEMBL3415877 | — | — | 1 | 5.49 |
| CHEMBL3415882 | — | — | 1 | 5.46 |
| CHEMBL3415867 | — | — | 1 | 5.44 |
| CHEMBL1962575 | — | — | 1 | 5.32 |
| CHEMBL3415878 | — | — | 1 | 5.13 |
| CHEMBL3415870 | — | — | 1 | 5.10 |
| CHEMBL3415881 | — | — | 1 | 5.09 |
| CHEMBL3415883 | — | — | 1 | 5.06 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.39 |
| CHEMBL3415880 | — | — | 1 | 4.12 |
| CHEMBL3415879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3415868 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL596333 | ISOCRYPTOLEPINE | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3415873 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3415869 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3415871 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL3415872 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL3415875 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3415874 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL3415876 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3415877 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3415882 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL3415867 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL1962575 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL3415878 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL3415870 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3415881 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3415883 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 40470.0 | nM | 4.39 |
| CHEMBL3415880 | — | IC50 | = | 75610.0 | nM | 4.12 |
| CHEMBL3415879 | — | IC50 | - | — | - |