Assay Detail
Binding
CHEMBL3418204
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Inhibition of human recombinant MAOA expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by luminescence assay
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.86 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416427 | — | — | 1 | 7.62 |
| CHEMBL3416432 | — | — | 1 | 7.60 |
| CHEMBL3416425 | — | — | 1 | 7.51 |
| CHEMBL3416431 | — | — | 1 | 7.43 |
| CHEMBL3416426 | — | — | 1 | 7.41 |
| CHEMBL3416434 | — | — | 1 | 7.16 |
| CHEMBL3416433 | — | — | 1 | 6.19 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.97 |
| CHEMBL3416428 | — | — | 1 | 5.86 |
| CHEMBL3416429 | — | — | 1 | 5.81 |
| CHEMBL3416430 | — | — | 2 | - |
| CHEMBL3416436 | — | — | 1 | - |
| CHEMBL3416435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416427 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3416432 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3416425 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3416431 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3416426 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3416434 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3416433 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3416428 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3416429 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3416430 | — | IC50 | - | — | - | |
| CHEMBL3416430 | — | IC50 | - | — | - | |
| CHEMBL3416436 | — | IC50 | - | — | - | |
| CHEMBL3416435 | — | IC50 | - | — | - |