Assay Detail
Binding
CHEMBL3418205
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Inhibition of human recombinant MAOB expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by luminescence assay
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.79 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 6.05 |
| CHEMBL3416425 | — | — | 1 | 5.05 |
| CHEMBL3416426 | — | — | 1 | 4.91 |
| CHEMBL3416427 | — | — | 1 | 4.77 |
| CHEMBL3416431 | — | — | 1 | 4.72 |
| CHEMBL3416432 | — | — | 1 | 4.67 |
| CHEMBL3416434 | — | — | 1 | 4.10 |
| CHEMBL3416429 | — | — | 1 | 4.07 |
| CHEMBL3416430 | — | — | 2 | - |
| CHEMBL3416435 | — | — | 1 | - |
| CHEMBL3416436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3416425 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL3416426 | — | IC50 | = | 12290.0 | nM | 4.91 |
| CHEMBL3416427 | — | IC50 | = | 16810.0 | nM | 4.77 |
| CHEMBL3416431 | — | IC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL3416432 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL3416434 | — | IC50 | = | 80070.0 | nM | 4.10 |
| CHEMBL3416429 | — | IC50 | = | 84700.0 | nM | 4.07 |
| CHEMBL3416430 | — | IC50 | - | — | - | |
| CHEMBL3416430 | — | IC50 | - | — | - | |
| CHEMBL3416435 | — | IC50 | - | — | - | |
| CHEMBL3416436 | — | IC50 | - | — | - |