Assay Detail
Binding
CHEMBL3418215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE incubated for 15 mins using acetylcholine iodide substrate by colorimetric Ellman's method
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.66 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.85 |
| CHEMBL3416669 | — | — | 1 | 6.80 |
| CHEMBL3416668 | — | — | 1 | 6.54 |
| CHEMBL3416645 | — | — | 1 | 6.46 |
| CHEMBL3416658 | — | — | 1 | 6.38 |
| CHEMBL3416673 | — | — | 1 | 6.29 |
| CHEMBL3416644 | — | — | 1 | 6.26 |
| CHEMBL3416657 | — | — | 1 | 6.19 |
| CHEMBL3416662 | — | — | 1 | 6.19 |
| CHEMBL3416661 | — | — | 1 | 6.11 |
| CHEMBL3416654 | — | — | 1 | 6.07 |
| CHEMBL3416672 | — | — | 1 | 6.06 |
| CHEMBL3416653 | — | — | 1 | 5.93 |
| CHEMBL3416667 | — | — | 1 | 5.88 |
| CHEMBL3416670 | — | — | 1 | 5.79 |
| CHEMBL3416643 | — | — | 1 | 5.71 |
| CHEMBL3416639 | — | — | 1 | 5.65 |
| CHEMBL3416649 | — | — | 1 | 5.61 |
| CHEMBL3416638 | — | — | 1 | 5.49 |
| CHEMBL3416665 | — | — | 1 | 5.48 |
| CHEMBL3416660 | — | — | 1 | 5.26 |
| CHEMBL3416637 | — | — | 1 | 5.26 |
| CHEMBL3416642 | — | — | 1 | 5.10 |
| CHEMBL3416659 | — | — | 1 | 5.00 |
| CHEMBL3416651 | — | — | 1 | 4.96 |
| CHEMBL3416652 | — | — | 1 | 4.92 |
| CHEMBL3416671 | — | — | 1 | 4.91 |
| CHEMBL3416674 | — | — | 1 | 4.82 |
| CHEMBL3416656 | — | — | 1 | 4.81 |
| CHEMBL3416655 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3416669 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3416668 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL3416645 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL3416658 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL3416673 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL3416644 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL3416657 | — | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL3416662 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL3416661 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL3416654 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL3416672 | — | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL3416653 | — | IC50 | = | 1178.0 | nM | 5.93 |
| CHEMBL3416667 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3416670 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3416643 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3416639 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3416649 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL3416638 | — | IC50 | = | 3237.0 | nM | 5.49 |
| CHEMBL3416665 | — | IC50 | = | 3287.0 | nM | 5.48 |
| CHEMBL3416637 | — | IC50 | = | 5517.0 | nM | 5.26 |
| CHEMBL3416660 | — | IC50 | = | 5442.0 | nM | 5.26 |
| CHEMBL3416642 | — | IC50 | = | 7899.0 | nM | 5.10 |
| CHEMBL3416659 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL3416651 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3416652 | — | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL3416671 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3416674 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3416656 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3416655 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL3416646 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL1201092 | RIVASTIGMINE TARTRATE | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL1807491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1171364 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416641 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416640 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1946828 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416663 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416664 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3416666 | — | IC50 | > | 100000.0 | nM | - |