Assay Detail
Binding
CHEMBL3418256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Moloney murine leukemia virus reverse transcriptase polymerase activity using Td100/Pd18 DNA-DNA substrate incubated for 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Moloney murine leukemia virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gag-Pol polyprotein (CHEMBL3562) ↗| Type | SINGLE PROTEIN |
| Organism | Moloney murine leukemia virus isolate Shinnick |
Publication
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.25 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414871 | — | — | 1 | 5.62 |
| CHEMBL3414876 | — | — | 1 | 5.55 |
| CHEMBL3414864 | — | — | 1 | 5.51 |
| CHEMBL3414857 | — | — | 1 | 5.50 |
| CHEMBL3414870 | — | — | 1 | 5.41 |
| CHEMBL3414862 | — | — | 1 | 5.16 |
| CHEMBL3414860 | — | — | 1 | 5.15 |
| CHEMBL3414868 | — | — | 1 | 5.07 |
| CHEMBL3414867 | — | — | 1 | 4.96 |
| CHEMBL3414869 | — | — | 1 | 4.96 |
| CHEMBL3414865 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414871 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3414876 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3414864 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3414857 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3414870 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3414862 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3414860 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3414868 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3414867 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3414869 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3414865 | — | IC50 | = | 13000.0 | nM | 4.89 |