Assay Detail
Binding
CHEMBL3418336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-labeled dUTP incorporation into DNA using poly(A) x oligo(dT)15 as template/primer after 1 hr by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.81 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 6.89 |
| CHEMBL3415144 | — | — | 1 | 6.77 |
| CHEMBL3415142 | — | — | 1 | 6.58 |
| CHEMBL3415140 | — | — | 1 | 6.44 |
| CHEMBL3415138 | — | — | 1 | 6.40 |
| CHEMBL3415148 | — | — | 1 | 6.39 |
| CHEMBL3415146 | — | — | 1 | 6.33 |
| CHEMBL3415134 | — | — | 1 | 6.09 |
| CHEMBL3415150 | — | — | 1 | 5.96 |
| CHEMBL3415151 | — | — | 1 | 5.89 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.62 |
| CHEMBL3415149 | — | — | 1 | 5.39 |
| CHEMBL3415139 | — | — | 1 | 5.33 |
| CHEMBL3415145 | — | — | 1 | 5.26 |
| CHEMBL3415136 | — | — | 1 | 5.24 |
| CHEMBL3415141 | — | — | 1 | 5.23 |
| CHEMBL3415147 | — | — | 1 | 4.96 |
| CHEMBL3415143 | — | — | 1 | 4.85 |
| CHEMBL3415137 | — | — | 1 | 4.82 |
| CHEMBL3415135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3415144 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3415142 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3415140 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3415138 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3415148 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3415146 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3415134 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3415150 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3415151 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3415149 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3415139 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3415145 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3415136 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3415141 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3415147 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3415143 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3415137 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3415135 | — | IC50 | = | 334000.0 | nM | - |