Assay Detail
Binding
CHEMBL3418528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation counting
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 9.00 |
| CHEMBL3415613 | — | — | 1 | 8.82 |
| CHEMBL3415617 | — | — | 1 | 8.70 |
| CHEMBL3415785 | — | — | 1 | 8.22 |
| CHEMBL3415614 | — | — | 1 | 8.05 |
| CHEMBL3415780 | — | — | 1 | 8.05 |
| CHEMBL3415795 | — | — | 1 | 7.70 |
| CHEMBL3415802 | — | — | 1 | 7.70 |
| CHEMBL3415793 | — | — | 1 | 7.60 |
| CHEMBL3415804 | — | — | 1 | 7.48 |
| CHEMBL3415798 | — | — | 1 | 7.48 |
| CHEMBL3415816 | — | — | 1 | 7.30 |
| CHEMBL3415810 | — | — | 1 | 7.30 |
| CHEMBL3415805 | — | — | 1 | 7.22 |
| CHEMBL3415797 | — | — | 1 | 7.22 |
| CHEMBL3415788 | — | — | 1 | 7.22 |
| CHEMBL3415615 | — | — | 1 | 7.22 |
| CHEMBL3415820 | — | — | 1 | 7.16 |
| CHEMBL3415818 | — | — | 1 | 7.16 |
| CHEMBL3415801 | — | — | 1 | 7.10 |
| CHEMBL3415817 | — | — | 1 | 7.10 |
| CHEMBL3415819 | — | — | 1 | 7.10 |
| CHEMBL3415815 | — | — | 1 | 7.10 |
| CHEMBL3415800 | — | — | 1 | 7.05 |
| CHEMBL3415792 | — | — | 1 | 7.05 |
| CHEMBL3415616 | — | — | 1 | 7.00 |
| CHEMBL3415789 | — | — | 1 | 7.00 |
| CHEMBL3415814 | — | — | 1 | 7.00 |
| CHEMBL3415612 | — | — | 1 | 6.40 |
| CHEMBL3415794 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3415613 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3415617 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3415785 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3415614 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3415780 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3415795 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3415802 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3415793 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3415798 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3415804 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3415816 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3415810 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3415615 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3415788 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3415805 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3415797 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3415820 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3415818 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3415815 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3415819 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3415801 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3415817 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3415800 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3415792 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3415616 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3415789 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3415814 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3415612 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3415794 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3415796 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3415791 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3415803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415807 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415799 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415809 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3415790 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3415808 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3414586 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3415806 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3415787 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415813 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415812 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3415811 | — | IC50 | > | 100.0 | nM | - |