Assay Detail
Functional
CHEMBL3418581
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Anticancer activity against human HepG2 cells assessed as cell survival after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of celastrol derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.34 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417317 | — | — | 1 | 6.55 |
| CHEMBL3417316 | — | — | 1 | 6.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.06 |
| CHEMBL3417318 | — | — | 1 | 5.51 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.40 |
| CHEMBL3417322 | — | — | 1 | 5.28 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.23 |
| CHEMBL3417321 | — | — | 1 | 5.06 |
| CHEMBL3417314 | — | — | 1 | 4.97 |
| CHEMBL3417315 | — | — | 1 | 4.95 |
| CHEMBL3417313 | — | — | 1 | 4.82 |
| CHEMBL3417320 | — | — | 1 | 4.79 |
| CHEMBL3417319 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417317 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3417316 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3417318 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL301982 | CELASTROL | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL3417322 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL3417321 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3417314 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3417315 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3417313 | — | IC50 | = | 15190.0 | nM | 4.82 |
| CHEMBL3417320 | — | IC50 | = | 16380.0 | nM | 4.79 |
| CHEMBL3417319 | — | IC50 | = | 22700.0 | nM | 4.64 |