Assay Detail
Binding
CHEMBL3418582
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Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of celastrol derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.60 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417316 | — | — | 1 | 6.96 |
| CHEMBL3417317 | — | — | 1 | 6.47 |
| CHEMBL27323 | — | — | 1 | 6.39 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.11 |
| CHEMBL3417322 | — | — | 1 | 5.85 |
| CHEMBL3417321 | — | — | 1 | 5.70 |
| CHEMBL3417319 | — | — | 1 | 5.10 |
| CHEMBL3417314 | — | — | 1 | 4.82 |
| CHEMBL3417320 | — | — | 1 | 4.82 |
| CHEMBL3417313 | — | — | 1 | 4.73 |
| CHEMBL3417315 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417316 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3417317 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL27323 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL301982 | CELASTROL | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3417322 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3417321 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3417319 | — | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL3417314 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3417320 | — | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL3417313 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL3417315 | — | IC50 | = | 21010.0 | nM | 4.68 |