Assay Detail
Binding
CHEMBL3418803
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Inhibition of human cytosolic form of carbonic anhydrase-2 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.77 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL3416235 | — | — | 1 | 7.89 |
| CHEMBL3416241 | — | — | 1 | 7.12 |
| CHEMBL3040927 | — | — | 1 | 6.43 |
| CHEMBL3416247 | — | — | 1 | 6.14 |
| CHEMBL3416240 | — | — | 1 | 5.97 |
| CHEMBL3416242 | — | — | 1 | 5.95 |
| CHEMBL3416226 | — | — | 1 | - |
| CHEMBL3416228 | — | — | 1 | - |
| CHEMBL3416229 | — | — | 1 | - |
| CHEMBL2408560 | — | — | 1 | - |
| CHEMBL3416230 | — | — | 1 | - |
| CHEMBL3416237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3416235 | — | Ki | = | 12.95 | nM | 7.89 |
| CHEMBL3416241 | — | Ki | = | 75.22 | nM | 7.12 |
| CHEMBL3040927 | — | Ki | = | 370.02 | nM | 6.43 |
| CHEMBL3416247 | — | Ki | = | 722.05 | nM | 6.14 |
| CHEMBL3416240 | — | Ki | = | 1064.56 | nM | 5.97 |
| CHEMBL3416242 | — | Ki | = | 1112.0 | nM | 5.95 |
| CHEMBL3416226 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416228 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416229 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2408560 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416230 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416237 | — | Ki | > | 10000.0 | nM | - |