Assay Detail
Binding
CHEMBL3418804
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Inhibition of human membrane associated form of carbonic anhydrase-9 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.62 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416235 | — | — | 1 | 7.85 |
| CHEMBL3416247 | — | — | 1 | 7.74 |
| CHEMBL3416229 | — | — | 1 | 7.70 |
| CHEMBL2408560 | — | — | 1 | 7.68 |
| CHEMBL3416241 | — | — | 1 | 7.64 |
| CHEMBL3416226 | — | — | 1 | 7.62 |
| CHEMBL3416237 | — | — | 1 | 7.61 |
| CHEMBL3416242 | — | — | 1 | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL3416240 | — | — | 1 | 7.59 |
| CHEMBL3040927 | — | — | 1 | 7.53 |
| CHEMBL3416230 | — | — | 1 | 7.49 |
| CHEMBL3416228 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416235 | — | Ki | = | 14.26 | nM | 7.85 |
| CHEMBL3416247 | — | Ki | = | 18.39 | nM | 7.74 |
| CHEMBL3416229 | — | Ki | = | 19.91 | nM | 7.70 |
| CHEMBL2408560 | — | Ki | = | 20.93 | nM | 7.68 |
| CHEMBL3416241 | — | Ki | = | 23.04 | nM | 7.64 |
| CHEMBL3416226 | — | Ki | = | 23.84 | nM | 7.62 |
| CHEMBL3416237 | — | Ki | = | 24.74 | nM | 7.61 |
| CHEMBL3416242 | — | Ki | = | 25.24 | nM | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3416240 | — | Ki | = | 25.58 | nM | 7.59 |
| CHEMBL3040927 | — | Ki | = | 29.75 | nM | 7.53 |
| CHEMBL3416230 | — | Ki | = | 32.09 | nM | 7.49 |
| CHEMBL3416228 | — | Ki | = | 37.62 | nM | 7.42 |