Assay Detail
Binding
CHEMBL3418911
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Inhibition of Respiratory syncytial virus RNA polymerase in crude RSV RNP complex assessed as inhibition of [33P]CMP incorporation into RNA chain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Respiratory syncytial virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417273 | — | — | 1 | 8.00 |
| CHEMBL3417275 | — | — | 1 | 7.70 |
| CHEMBL3417284 | — | — | 1 | 7.16 |
| CHEMBL3417280 | — | — | 1 | 7.05 |
| CHEMBL3417277 | — | — | 1 | 7.05 |
| CHEMBL3417272 | — | — | 1 | 7.00 |
| CHEMBL3417274 | — | — | 1 | 6.92 |
| CHEMBL3417279 | — | — | 1 | 6.89 |
| CHEMBL3417276 | — | — | 1 | 6.82 |
| CHEMBL3417278 | — | — | 1 | 6.82 |
| CHEMBL3417271 | — | — | 1 | 6.70 |
| CHEMBL3417282 | — | — | 1 | 6.70 |
| CHEMBL3417270 | — | — | 1 | 6.62 |
| CHEMBL3417269 | — | — | 1 | 6.52 |
| CHEMBL3417288 | — | — | 1 | 5.80 |
| CHEMBL3417281 | — | — | 1 | 5.70 |
| CHEMBL3417283 | — | — | 1 | 5.57 |
| CHEMBL3417285 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417273 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3417275 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3417284 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3417280 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3417277 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3417272 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3417274 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3417279 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3417276 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3417278 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3417271 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3417282 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3417270 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3417269 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3417288 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3417281 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3417283 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3417285 | — | IC50 | = | 4900.0 | nM | 5.31 |