Assay Detail
Functional
CHEMBL3418925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 4.78 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32856 | — | — | 1 | 5.31 |
| CHEMBL3415863 | — | — | 1 | 5.19 |
| CHEMBL408894 | — | — | 1 | 5.10 |
| CHEMBL3416018 | — | — | 1 | 5.05 |
| CHEMBL32857 | — | — | 1 | 5.03 |
| CHEMBL1802076 | — | — | 1 | 5.01 |
| CHEMBL3415861 | — | — | 1 | 5.00 |
| CHEMBL3416017 | — | — | 1 | 4.94 |
| CHEMBL32207 | — | — | 1 | 4.91 |
| CHEMBL3415862 | — | — | 1 | 4.91 |
| CHEMBL609576 | — | — | 1 | 4.91 |
| CHEMBL32339 | 4,2',4',6'-TETRAMETHOXYCHALCONE | — | 1 | 4.87 |
| CHEMBL468181 | — | — | 1 | 4.86 |
| CHEMBL589609 | — | — | 1 | 4.85 |
| CHEMBL3415857 | — | — | 1 | 4.84 |
| CHEMBL3415858 | — | — | 1 | 4.83 |
| CHEMBL467145 | — | — | 1 | 4.82 |
| CHEMBL3415865 | — | — | 1 | 4.82 |
| CHEMBL32584 | — | — | 1 | 4.79 |
| CHEMBL3416013 | — | — | 1 | 4.79 |
| CHEMBL3416019 | — | — | 1 | 4.78 |
| CHEMBL3415864 | — | — | 1 | 4.78 |
| CHEMBL3416016 | — | — | 1 | 4.77 |
| CHEMBL3416010 | — | — | 1 | 4.75 |
| CHEMBL3416014 | — | — | 1 | 4.74 |
| CHEMBL494264 | — | — | 1 | 4.74 |
| CHEMBL3416011 | — | — | 1 | 4.73 |
| CHEMBL3416009 | — | — | 1 | 4.73 |
| CHEMBL601294 | — | — | 1 | 4.69 |
| CHEMBL1165326 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32856 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3415863 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL408894 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3416018 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL32857 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1802076 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3415861 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3416017 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL32207 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3415862 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL609576 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL32339 | 4,2',4',6'-TETRAMETHOXYCHALCONE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL468181 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL589609 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3415857 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3415858 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL467145 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3415865 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL32584 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3416013 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3416019 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL3415864 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL3416016 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3416010 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL3416014 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL494264 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL3416011 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3416009 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL601294 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL1165326 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2335481 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3416015 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL494612 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL1165313 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL253896 | XANTHOHUMOL | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3120611 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL507998 | HELICHRYSETIN | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL3416012 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3416020 | — | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL593899 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL589608 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3415860 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3415859 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL595815 | — | IC50 | > | 50000.0 | nM | - |