Assay Detail
Binding
CHEMBL3419218
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Inhibition of electric eel AChE pre-incubated for 3 mins before acetylthiocholine substrate addition by Ellman's reagent based spectrophotometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.79 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416513 | — | — | 1 | 6.91 |
| CHEMBL3416509 | — | — | 1 | 6.76 |
| CHEMBL3416507 | — | — | 1 | 6.72 |
| CHEMBL3416519 | — | — | 1 | 6.68 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.55 |
| CHEMBL3416516 | — | — | 1 | 6.25 |
| CHEMBL3416515 | — | — | 1 | 6.00 |
| CHEMBL3416512 | — | — | 1 | 5.96 |
| CHEMBL3416510 | — | — | 1 | 5.72 |
| CHEMBL3416505 | — | — | 1 | 5.62 |
| CHEMBL3416521 | — | — | 1 | 5.57 |
| CHEMBL3416508 | — | — | 1 | 5.48 |
| CHEMBL3416520 | — | — | 1 | 5.46 |
| CHEMBL3416517 | — | — | 1 | 5.19 |
| CHEMBL3416514 | — | — | 1 | 5.17 |
| CHEMBL3416506 | — | — | 1 | 5.09 |
| CHEMBL3416511 | — | — | 1 | 4.86 |
| CHEMBL3416518 | — | — | 1 | 4.30 |
| CHEMBL3416504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416513 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3416509 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3416507 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3416519 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL95 | TACRINE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3416516 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL3416515 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3416512 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3416510 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3416505 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3416521 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3416508 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3416520 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3416517 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL3416514 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL3416506 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL3416511 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3416518 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3416504 | — | IC50 | = | 158000.0 | nM | - |