Assay Detail
Binding
CHEMBL3419310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against pSG5-Gal4-tagged human PPAR-beta/delta ligand binding domain expressed in COS1 cells assessed as inhibition of GW501516-induced receptor activation incubated for 19 hrs by pGL3-5XUAS-SV40 luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.15 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598608 | — | — | 1 | 5.30 |
| CHEMBL3416764 | — | — | 1 | 5.00 |
| CHEMBL3416765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598608 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3416764 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3416765 | — | IC50 | - | — | - |