Assay Detail
Binding
CHEMBL3419948
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Agonist activity at 5HT2C receptor (unknown origin) relative to control
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.72 | 9.96 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494947 | — | — | 2 | 9.96 |
| CHEMBL2110670 | VABICASERIN | 2.0 | 2 | 8.10 |
| CHEMBL1628670 | — | — | 2 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494947 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL2110670 | VABICASERIN | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1628670 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2110670 | VABICASERIN | Emax | = | 100.0 | % | - |
| CHEMBL494947 | — | Emax | = | 93.0 | % | - |
| CHEMBL1628670 | — | Emax | = | 90.0 | % | - |