Assay Detail
Binding
CHEMBL3420008
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Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.61 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414711 | — | — | 1 | 6.82 |
| CHEMBL3414710 | — | — | 1 | 6.55 |
| CHEMBL3414709 | — | — | 1 | 6.33 |
| CHEMBL3414700 | — | — | 1 | 6.17 |
| CHEMBL3414707 | — | — | 1 | 6.16 |
| CHEMBL3414708 | — | — | 1 | 6.07 |
| CHEMBL3414701 | — | — | 1 | 5.97 |
| CHEMBL3414706 | — | — | 1 | 5.29 |
| CHEMBL3414705 | — | — | 1 | 4.76 |
| CHEMBL3414703 | — | — | 1 | 4.68 |
| CHEMBL3414702 | — | — | 1 | 4.44 |
| CHEMBL3414704 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414711 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3414710 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3414709 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3414700 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3414707 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3414708 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3414701 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3414706 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3414705 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3414703 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3414702 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3414704 | — | IC50 | = | 88000.0 | nM | 4.06 |