Assay Detail
Binding
CHEMBL3420009
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Inhibition of CatD (unknown origin) by fluorescence polarization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.27 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414711 | — | — | 1 | 4.60 |
| CHEMBL3414710 | — | — | 1 | 4.35 |
| CHEMBL3414709 | — | — | 1 | 4.20 |
| CHEMBL3414707 | — | — | 1 | 4.14 |
| CHEMBL3414700 | — | — | 1 | 4.08 |
| CHEMBL3414701 | — | — | 1 | - |
| CHEMBL3414708 | — | — | 1 | - |
| CHEMBL3414706 | — | — | 1 | - |
| CHEMBL3414705 | — | — | 1 | - |
| CHEMBL3414704 | — | — | 1 | - |
| CHEMBL3414703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414711 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL3414710 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3414709 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3414707 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL3414700 | — | IC50 | = | 83100.0 | nM | 4.08 |
| CHEMBL3414701 | — | IC50 | > | 81000.0 | nM | - |
| CHEMBL3414708 | — | IC50 | > | 91400.0 | nM | - |
| CHEMBL3414706 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3414705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3414704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3414703 | — | IC50 | > | 100000.0 | nM | - |