Assay Detail
Functional
CHEMBL3420161
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Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of salinomycin conjugates with floxuridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.59 | 6.82 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.82 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 6.44 |
| CHEMBL3416849 | — | — | 1 | 5.84 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.33 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 4.72 |
| CHEMBL3416848 | — | — | 1 | 4.38 |
| CHEMBL1791034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3416849 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 19070.0 | nM | 4.72 |
| CHEMBL3416848 | — | IC50 | = | 41250.0 | nM | 4.38 |
| CHEMBL1791034 | — | Inhibition | = | 43.0 | % | - |