Assay Detail
Binding
CHEMBL3420397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel expressed in CHO cells by patch clamp method
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.89 | 6.57 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416047 | — | — | 1 | 6.57 |
| CHEMBL3416055 | — | — | 1 | 5.70 |
| CHEMBL3416051 | — | — | 1 | 5.40 |
| CHEMBL3416063 | — | — | 1 | - |
| CHEMBL3416067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416047 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3416055 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3416051 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3416063 | — | Inhibition | - | % | - | |
| CHEMBL3416067 | — | Inhibition | - | % | - |