Assay Detail
Binding
CHEMBL3420440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam spectrophotometry
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsomal |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.04 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415249 | — | — | 1 | 6.10 |
| CHEMBL3415256 | — | — | 1 | 6.10 |
| CHEMBL3415251 | — | — | 1 | 6.05 |
| CHEMBL3415242 | — | — | 1 | 6.05 |
| CHEMBL3415244 | — | — | 1 | 6.05 |
| CHEMBL3415252 | — | — | 1 | 6.05 |
| CHEMBL3415253 | — | — | 1 | 6.05 |
| CHEMBL3415250 | — | — | 1 | 4.95 |
| CHEMBL1404869 | — | — | 1 | 4.95 |
| CHEMBL3415248 | — | — | 1 | 4.90 |
| CHEMBL3415255 | — | — | 1 | 4.54 |
| CHEMBL2414451 | — | — | 1 | 4.47 |
| CHEMBL3415254 | — | — | 1 | 4.45 |
| CHEMBL2414452 | — | — | 1 | 4.44 |
| CHEMBL3415243 | — | — | 1 | 4.39 |
| CHEMBL2414449 | — | — | 1 | 4.38 |
| CHEMBL1452451 | — | — | 1 | 4.35 |
| CHEMBL3415246 | — | — | 1 | 4.31 |
| CHEMBL3415247 | — | — | 1 | 4.13 |
| CHEMBL2414447 | — | — | 1 | 4.11 |
| CHEMBL2414444 | — | — | 1 | - |
| CHEMBL3415245 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415249 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3415256 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3415251 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3415242 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3415244 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3415252 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3415253 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3415250 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1404869 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3415248 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3415255 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL2414451 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL3415254 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL2414452 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL3415243 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2414449 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL1452451 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL3415246 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3415247 | — | IC50 | = | 74100.0 | nM | 4.13 |
| CHEMBL2414447 | — | IC50 | = | 77600.0 | nM | 4.11 |
| CHEMBL2414444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3415245 | — | IC50 | > | 100000.0 | nM | - |