Assay Detail
Functional
CHEMBL3420442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.64 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415244 | — | — | 1 | 4.96 |
| CHEMBL3415248 | — | — | 1 | 4.56 |
| CHEMBL3415249 | — | — | 1 | 4.56 |
| CHEMBL482686 | — | — | 1 | 4.56 |
| CHEMBL2414454 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415244 | — | IC50 | = | 10980.0 | nM | 4.96 |
| CHEMBL3415248 | — | IC50 | = | 27510.0 | nM | 4.56 |
| CHEMBL3415249 | — | IC50 | = | 27460.0 | nM | 4.56 |
| CHEMBL482686 | — | IC50 | = | 27570.0 | nM | 4.56 |
| CHEMBL2414454 | — | IC50 | = | 27690.0 | nM | 4.56 |