Assay Detail
Binding
CHEMBL3420730
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Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.94 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414710 | — | — | 1 | 7.62 |
| CHEMBL3414711 | — | — | 1 | 7.60 |
| CHEMBL3414708 | — | — | 1 | 7.52 |
| CHEMBL3414707 | — | — | 1 | 7.41 |
| CHEMBL3414700 | — | — | 1 | 7.23 |
| CHEMBL3414709 | — | — | 1 | 7.23 |
| CHEMBL3414701 | — | — | 1 | 7.21 |
| CHEMBL3414706 | — | — | 1 | 6.58 |
| CHEMBL3414705 | — | — | 1 | 6.43 |
| CHEMBL3414703 | — | — | 1 | 6.07 |
| CHEMBL3414704 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414710 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3414711 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3414708 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3414707 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3414700 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3414709 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3414701 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3414706 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL3414705 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL3414703 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3414704 | — | IC50 | = | 3940.0 | nM | 5.41 |