Assay Detail
Binding
CHEMBL3420957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli RNase H pre-incubated for 10 mins before HTS-1 RNA/DNA duplex substrate addition by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.39 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414871 | — | — | 1 | 5.60 |
| CHEMBL3414867 | — | — | 1 | 5.54 |
| CHEMBL3414869 | — | — | 1 | 5.51 |
| CHEMBL3414864 | — | — | 1 | 5.50 |
| CHEMBL3414868 | — | — | 1 | 5.50 |
| CHEMBL3414865 | — | — | 1 | 5.47 |
| CHEMBL3414876 | — | — | 1 | 5.40 |
| CHEMBL3414860 | — | — | 1 | 5.35 |
| CHEMBL3414857 | — | — | 1 | 5.19 |
| CHEMBL3414862 | — | — | 1 | 5.14 |
| CHEMBL3414870 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414871 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3414867 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3414869 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3414864 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3414868 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3414865 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3414876 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3414860 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3414857 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3414862 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3414870 | — | IC50 | = | 7200.0 | nM | 5.14 |