Assay Detail
Binding
CHEMBL3421397
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Antagonist activity at Sprague-Dawley rat prostatic vas deferens adrenergic alpha-1A receptor after 20 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 7.47 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415020 | — | — | 1 | 8.13 |
| CHEMBL3415012 | — | — | 1 | 8.10 |
| CHEMBL3415014 | — | — | 1 | 7.90 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.90 |
| CHEMBL3415011 | — | — | 1 | 7.58 |
| CHEMBL142635 | NAFTOPIDIL | 4.0 | 1 | 7.48 |
| CHEMBL3415018 | — | — | 1 | 7.32 |
| CHEMBL3415019 | — | — | 1 | 7.28 |
| CHEMBL3415015 | — | — | 1 | 7.26 |
| CHEMBL3415016 | — | — | 1 | 7.23 |
| CHEMBL3415017 | — | — | 1 | 7.16 |
| CHEMBL3414578 | — | — | 1 | 7.11 |
| CHEMBL3415013 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415020 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL3415012 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL3415014 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL611 | TERAZOSIN | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL3415011 | — | Kd | = | 26.3 | nM | 7.58 |
| CHEMBL142635 | NAFTOPIDIL | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL3415018 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL3415019 | — | Kd | = | 52.48 | nM | 7.28 |
| CHEMBL3415015 | — | Kd | = | 54.95 | nM | 7.26 |
| CHEMBL3415016 | — | Kd | = | 58.88 | nM | 7.23 |
| CHEMBL3415017 | — | Kd | = | 69.18 | nM | 7.16 |
| CHEMBL3414578 | — | Kd | = | 77.62 | nM | 7.11 |
| CHEMBL3415013 | — | Kd | = | 194.98 | nM | 6.71 |