Assay Detail
Functional
CHEMBL3421423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Semliki forest virus Vietnam infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Semliki Forest virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.47 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.86 |
| CHEMBL3414614 | — | — | 1 | 4.69 |
| CHEMBL3414613 | — | — | 1 | 4.21 |
| CHEMBL3414615 | — | — | 1 | 4.12 |
| CHEMBL3414606 | — | — | 1 | - |
| CHEMBL3414607 | — | — | 1 | - |
| CHEMBL3414608 | — | — | 1 | - |
| CHEMBL3414609 | — | — | 1 | - |
| CHEMBL3414610 | — | — | 1 | - |
| CHEMBL3414611 | — | — | 1 | - |
| CHEMBL3414612 | — | — | 1 | - |
| CHEMBL3414616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3414614 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL3414613 | — | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3414615 | — | EC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL3414606 | — | EC50 | - | — | - | |
| CHEMBL3414607 | — | EC50 | > | 157000.0 | nM | - |
| CHEMBL3414608 | — | EC50 | > | 116000.0 | nM | - |
| CHEMBL3414609 | — | EC50 | > | 165000.0 | nM | - |
| CHEMBL3414610 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL3414611 | — | EC50 | > | 145000.0 | nM | - |
| CHEMBL3414612 | — | EC50 | > | 140000.0 | nM | - |
| CHEMBL3414616 | — | EC50 | > | 163000.0 | nM | - |