Assay Detail
Binding
CHEMBL3423740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel myricetin derivatives: Design, synthesis and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.35 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27323 | — | — | 1 | 6.77 |
| CHEMBL3423397 | — | — | 1 | 6.04 |
| CHEMBL3423394 | — | — | 1 | 5.74 |
| CHEMBL3423391 | — | — | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.63 |
| CHEMBL3423386 | — | — | 1 | 5.51 |
| CHEMBL3423388 | — | — | 1 | 4.71 |
| CHEMBL3423385 | — | — | 1 | 4.54 |
| CHEMBL3423384 | — | — | 1 | 4.45 |
| CHEMBL3423389 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27323 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3423397 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3423394 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3423391 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL3423386 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL3423388 | — | IC50 | = | 19660.0 | nM | 4.71 |
| CHEMBL3423385 | — | IC50 | = | 28910.0 | nM | 4.54 |
| CHEMBL3423384 | — | IC50 | = | 35660.0 | nM | 4.45 |
| CHEMBL3423389 | — | IC50 | = | 40300.0 | nM | 4.39 |