Assay Detail
Binding
CHEMBL3424044
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Binding affinity to Keap1/Nrf2 complex (unknown origin) by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.18 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402205 | — | — | 1 | 7.54 |
| CHEMBL3421645 | — | — | 1 | 7.52 |
| CHEMBL2069630 | — | — | 1 | 7.21 |
| CHEMBL3423015 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402205 | — | Kd | = | 28.7 | nM | 7.54 |
| CHEMBL3421645 | — | Kd | = | 30.1 | nM | 7.52 |
| CHEMBL2069630 | — | Kd | = | 61.9 | nM | 7.21 |
| CHEMBL3423015 | — | Kd | = | 352.0 | nM | 6.45 |