Assay Detail
Binding
CHEMBL3424203
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Inhibition of N-terminally tagged full-length HCV NS5B using biotinylated oligo(rU12), poly(rA) as template-primer assessed as incorporation of [3H]-UTP after 90 mins by Scintillation Proximity Assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366574 | — | — | 1 | 7.57 |
| CHEMBL590850 | — | — | 1 | 6.89 |
| CHEMBL3422105 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366574 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL590850 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3422105 | — | IC50 | = | 300.0 | nM | 6.52 |