Assay Detail
Binding
CHEMBL3424209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate BK) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Genome polyprotein (CHEMBL6040) ↗| Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
Publication
Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.73 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422106 | — | — | 1 | 8.00 |
| CHEMBL3422108 | — | — | 1 | 7.96 |
| CHEMBL3422107 | — | — | 1 | 7.72 |
| CHEMBL213832 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422106 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3422108 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3422107 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL213832 | — | IC50 | = | 58.0 | nM | 7.24 |