Assay Detail
Functional
CHEMBL3424210
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Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 cells assessed as inhibition of viral replication
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.39 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422106 | — | — | 1 | 6.89 |
| CHEMBL3422107 | — | — | 1 | 6.82 |
| CHEMBL3422108 | — | — | 1 | 6.29 |
| CHEMBL213832 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422106 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3422107 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3422108 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL213832 | — | EC50 | = | 2900.0 | nM | 5.54 |