Assay Detail
Binding
CHEMBL3424219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by scintillation proximity assay in presence of NADPH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.18 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422265 | — | — | 1 | 7.82 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 7.54 |
| CHEMBL3422416 | — | — | 1 | 7.47 |
| CHEMBL3422266 | — | — | 1 | 7.12 |
| CHEMBL3422264 | — | — | 1 | 6.71 |
| CHEMBL3422415 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422265 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL3422416 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL3422266 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL3422264 | — | IC50 | = | 194.5 | nM | 6.71 |
| CHEMBL3422415 | — | IC50 | = | 395.2 | nM | 6.40 |