Assay Detail
Functional
CHEMBL3424239
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Growth inhibition of mouse B16 cells by MTT method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.71 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.19 |
| CHEMBL3422422 | — | — | 1 | 4.83 |
| CHEMBL1630577 | ABAMECTIN COMPONENT B1A | -1.0 | 1 | 4.69 |
| CHEMBL3422424 | — | — | 1 | 4.46 |
| CHEMBL3422423 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3422422 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL1630577 | ABAMECTIN COMPONENT B1A | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL3422424 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL3422423 | — | IC50 | = | 40600.0 | nM | 4.39 |